Preoperative parathyroid localization. Relevance of MIBI SPECT-CT in adverse scenarios.

PURPOSE: Selective parathyroidectomy, the treatment of choice for primary hyperparathyroidism, requires precise preoperative localization. Our purpose was to compare the accuracy and concordance of pre-surgical MIBI parathyroid scintigraphy and ultrasonography, as well as to assess the relevance of hybrid acquisition (SPECT/CT) in compromised circumstances: low-weight or ectopic adenomas, coexisting thyroid disease and re-interventions. METHODS: The study included 223 patients with primary hyperparathyroidism operated in a single Surgical Unit from August 2016 to March 2021. Preoperative ultrasonography and double-phase MIBI were performed with early SPECT/CT acquisition. A minimally invasive surgical approach was initially attempted, except in patients with concomitant thyroid surgery or multiglandular parathyroid disease. RESULTS: Selective parathyroidectomy was accomplished in 179 patients (80.2%); cervicotomy and/or thoracoscopy in 44. Removal of the parathyroid lesion was achieved in 211 patients (94.6%), corresponding 204 (96.7%) to adenomas (37 ectopic). The cure rate was 94.2%. Preoperative MIBI SPECT/CT showed higher sensitivity and accuracy (84%; 80%) compared to ultrasound (72%; 71%), being more precise in defining the exact anatomical location (75.8% vs 68.7%). These differences reached statistical significance in ectopic glands. The existence of concomitant thyroid pathology did not decrease the sensitivity of SPECT/CT (84.2%). Mean parathyroid weight was 692.2mg (95%CI: 443.5-941) in MIBI-negative cases and 1145.9mg (95%CI: 983.6-1308.3) in MIBI-positive (p=0.001). Re-intervention was successful in the 8 patients with previous surgery. CONCLUSION: MIBI SPECT/CT presents greater sensitivity, accuracy and anatomical precision than ultrasound for preoperative parathyroid localization, even in the case of ectopic glands or coexisting thyroid pathology. The weight of the pathological gland is a significantly limiting factor.

Procedimiento radioguiado en la cirugía mínimamente invasiva del hiperparatiroidismo primario / Radio-guided procedure in minimally invasive surgery for primary hyperparathyroidism

La paratiroidectomía mínimamente invasiva, de elección en la mayoría de casos de hiperparatiroidismo primario, muestra una elevada tasa de detección, fundamentada en una precisa localización preoperatoria mediante gammagrafía con MIBI (SPECT/TC) y ecografía cervical. La paratiroidectomía mínimamente invasiva radioguiada es una técnica aún más efectiva, acorta los tiempos quirúrgicos y mantiene una mínima incisión y escasas complicaciones; permite además la comprobación inmediata de la exéresis de la lesión paratiroidea y es especialmente interesante en pacientes con adenomas ectópicos o antecedentes quirúrgicos cervicales. En el presente trabajo se exponen las indicaciones, los protocolos y las diferencias entre los dos procedimientos disponibles de cirugía radioguiada mínimamente invasiva de paratiroides (MIBI y ROLL). (AU)

Minimally invasive parathyroidectomy, of choice in most cases of primary hyperparathyroidism, shows a high detection rate, based on precise preoperative localization by MIBI scintigraphy (SPECT/CT) and neck ultrasound. Radio-guided minimally invasive parathyroidectomy is an even more effective technique, which shortens surgical times, maintains minimal incision and few complications, allows immediate verification of parathyroid adenoma removal and is especially interesting in patients with ectopic lesions or cervical surgical history. In this paper, the indications, protocols and differences between the two available radio-guided parathyroid surgery procedures (MIBI and ROLL) are exposed. (AU)

Radio-guided procedure in minimally invasive surgery for primary hyperparathyroidism.

Minimally invasive parathyroidectomy, of choice in most cases of primary hyperparathyroidism, shows a high detection rate, based on precise preoperative localization by MIBI scintigraphy (SPECT/CT) and neck ultrasound. Radioguided minimally invasive parathyroidectomy is an even more effective technique, which shortens surgical times, maintains minimal incision and few complications, allows immediate verification of parathyroid adenoma removal and is especially interesting in patients with ectopic lesions or cervical surgical history. In this paper, the indications, protocols and differences between the two available radioguided parathyroid surgery procedures (MIBI and R.O.L.L.) are exposed.

Utility of the continuous intraoperative neuromonitoring in the prevention of the recurrent laryngeal nerve paralysis during thyroid surgery. A prospective observational study / Utilidad de la neuromonitorización continua intraoperatoria en la prevención de la parálisis del nervio laríngeo recurrente durante la cirugía tiroidea. Un estudio observacional prospectivo

Background: The continuous intraoperative neuromonitoring (C-IONM) of the recurrent laryngeal nerve (RLN) could help reducing the incidence of nerve paralysis after thyroid surgery, in comparison with the mere anatomical visualization of the RLN. The objective is to assess the efficacy and utility of C-IONM as a predictive test for recurrent laryngeal nerve paralysis after thyroidectomy. Methods: A prospective observational study was performed in 248 patients who underwent thyroid surgery where C-IONM was applied, between September 2018 and December 2019, in a high-volume center. A previous and later laryngoscopy was performed, which allowed to evaluate the reliability of the C-IONM as a predictive test for recurrent paralysis. Sensitivity (SE), specificity (SP), positive predictive value (PPV), negative predictive value (NPV) were studied. Results: A total number of 171 thyroidectomies, 62 hemithyroidectomies, 15 totalization thyroidectomies and 27 thyroidectomy with cervical dissections were performed. Postoperative laryngoscopy was altered in 40 patients (16.12%). The SE, SP, PPV and NPV values ​​were 65%, 94.7%, 70.2% and 93.4% respectively. Conclusions: C-IONM is a safe technique that provides real-time information about anatomical and functional integrity of the RLN and can improve the results of thyroid surgery. (AU)

Introducción: La neuromonitorización continua intraoperatoria (C-IONM) del nervio laríngeo recurrente (RLN) puede contribuir a la reducción de la incidencia de parálisis nerviosa tras una cirugía tiroidea, en comparación con la mera visualización anatómica del RLN. El objetivo de este estudio es evaluar la fiabilidad de la NCIO de los nervios laríngeos recurrentes como prueba predictora de parálisis vocal postoperatoria. Material y métodos: Se trata de un estudio observacional prospectivo realizado en 248 pacientes intervenidos de patología tiroidea en los que se aplicó la C-IONM, entre Septiembre de 2018 y Diciembre de 2019 en un único centro de alto volumen. Se realizó una laringoscopia pre y post operatoria a todos los pacientes, lo que pudo determinar la fiabilidad de la C-IONM como test predictivo de la parálisis recurrencial tras cirugía tiroidea. Se hallaron los valores de sensibilidad (SE), especificidad (SP), valor predictivo positivo (PPV) y valor predictivo negativo (NPV) de dicha técnica. Resultados: Se realizaron un total de 171 tiroidectomías totales, 62 hemitiroidectomías, 15 tiroidectomías de totalización y 27 tiroidectomías con disección cervical. Se hallaron alteraciones en la laringoscopia postoperatoria en 40 pacientes (16,12%). Los valores de SE, SP, PPV y NPV fueron 65%, 94.7%, 70.2% y 93.4% respectivamente. Conclusiones: La C-IONM es una técnica segura que ofrece información anatómica y funcional del NLR en tiempo real y puede contribuir a mejorar los resultados de la cirugía tiroidea. (AU)